ENERGENESIS


ENERGENESIS



Get Your Energenesis Now!

Energenesis is currently sold out. Our next batch arrives in 4-6 weeks.

Purchasing now will ensure it is shipped to you as soon as it is in stock.

FREE shipping inside US
We send internationally!

(For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.)


What people say about Energenesis

The Big Key To REAL Energy Enhancement Isn’t Sugar and Stimulants – it’s Optimizing Your Mitochondria


Mitochondria. The powerhouses of the cell.

 

They are the absolute most critical physiological system involved in our energy levels. If you are dealing with fatigue, that is almost certainly a sure sign that your mitochondria are not functioning well.

Virtually all of the energy that powers virtually all the trillions of cells in your body comes from your mitochondria.


Here’s the problem: As you age, your mitochondria become damaged and dysfunctional.


And they even shrink in size. 

 

(Think of how a muscle shrinks or atrophies if it’s in a cast — the same thing happens to our mitochondria, our energy generators over time.)

 

Research has shown that for most people, from the age of 20-40, their mitochondrial capacity (the ability of our cells to produce energy) decreases by HALF. And then, from 40-70, it decreases by another HALF!

As a result, the energy your mitochondria produce naturally decreases over time, reducing your health and longevity — and ultimately, causing fatigue.

 

On top of that, stressors in our life — from psychological stress, to environmental toxins (like heavy metals and air pollutants), to a poor diet, to poor gut health, to chronic inflammation — all cause mitochondrial damage, dysfunction and shut down (they shift out of energy mode into a cell protection response). 

 

Research is now showing that these three things — the loss of mitochondria, the damage/dysfunction of mitochondria, and the shut down of mitochondria — are the primary factors that drive low energy levels.

 

In other words, if you’ve got low energy levels, it likely simply means that your mitochondria have become weak, damaged, dysfunctional, and switched off over time. 

 

Here’s the spectrum of energy, so you can visualize where you are on this continuum. 

Where are you on this spectrum?

 

If you’d like more energy, here’s what you need to know…

 

Supporting your mitochondrial health is the single most important thing you can do to help overcome fatigue and increase your energy levels.

 

There are 6 key pathways you need to build if you really want to build big healthy mitochondria that pump out energy all day long.

 

1. You Need BIGGER Mitochondria. Building the size of your mitochondria so they can produce more energy is one of the most important factors in increasing energy levels over time. 


2. You Need MORE Mitochondria (i.e. Mitochondrial Biogenesis). The more mitochondria you have, the bigger your “cellular engine” grows, the more energy you’re able to produce. Several ingredients in this list can actually stimulate this process of mitochondrial biogenesis – allowing your body to build more mitochondria from scratch.


3. It’s VITAL to Repair and Protect Your Cell Membranes. Research has shown that one of the most potent ways to improve energy levels is to repair the physical membranes of your mitochondria. (Several of the ingredients on this list can do this, but #1 and #2 are especially powerful).


4. You Need Cofactors Involved Mitochondria Energy Production. These are substances which facilitate the process of mitochondria producing cellular energy.


5. You Need To Recharge NAD+ Levels. NAD+ is a critical regulatory of mitochondrial energy production. Several key compounds in this list directly help rebuild our body’s supply of NAD+ (like #13, #20, #23, and #24).


6. You Need To Build Up Your Mitochondrial Internal Defense System (a.k.a. The NRF2 Pathway and the A.R.E.) People speak about the importance of antioxidants, but don’t realize that our cells’ internal antioxidant defense system is hundreds of times more powerful and more important. Several of the compounds in this list don’t just work as antioxidants, but even better, they build up the body’s internal cellular/mitochondrial antioxidant defense system — that makes our mitochondria more able to deal with stressors and protect themselves from damage, which ultimately means that instead of getting shut down, they stay in High Energy Mode pumping out energy.


Now that you understand all the background of how to build REAL ENERGY at the cellular level, let’s get into the most powerful compounds for building your mitochondria and your energy levels!


ENERGENESIS INGREDIENTS




ENERGENESIS INGREDIENTS



NT Factor® Phospholipids


This is one of the most powerful compounds for mitochondrial regeneration, probably the single most impressive individual supplement ever tested to help people overcome fatigue. 


NTFactor® is a compound used in lipid replacement therapy, a method of replacing damaged membrane phospholipids that accumulate during aging and in various clinical conditions in order to restore cellular and mitochondrial function. 


It has been shown to increase energy levels by a whopping 24–43% in people with chronic fatigue syndrome in just 4 weeks. [1-4]


And it has been shown to many other types of fatigue, including age-related fatigue, fatigue from chemical exposure, as well as reduce cancer-associated fatigue and the fatigue effects of cancer therapy by similar amounts, again, in just a few weeks of use! [5,6]

 

How does it work?

 

Mitochondria are wrapped in membranes composed of phospholipids.

These membranes (i.e. the phospholipids that compose them) get damaged. And when they’re damaged, they do two things:

 

  • The mitochondria don’t produce as much energy
  • The mitochondria create more oxidative stress and inflammation (basically, they create a vicious cycle whereby damaged mitochondria lead to more damaged mitochondria)

 

NTFactor® is a specially formulated and patented phospholipid formulation that consists of phospholipids that actually get absorbed into your bloodstream intact, and then get delivered to the cells and to the damaged mitochondria where they literally replace the old damaged phospholipids with new healthy ones.

 

That’s why this is such an amazing supplement — it’s literally like taking your mitochondria to the mechanic to be repaired. (That’s why it’s one of the key ingredients in Energenesis.)

 

Where else are you going to take ANYTHING that is proven in numerous studies to increase energy levels (in people with chronic fatigue) by up to 43% in just a few weeks?

 

This is an incredibly powerful supplement, and it’s truly a must-have supplement in your arsenal to increase your energy.


Astaxanthin


Astaxanthin is one of the most powerful non-stimulant ways to build up your cellular energy production. And it works through multiple powerful mechanisms, and has a massive amount of research supporting all kinds of seemingly miraculous health benefits. 


Astaxanthin is the red pigment in shrimp, salmon, krill and various other seafood, but it is originally made by algae (mainly Haematococcus pluvialis)


It is thought to be one of the most effective antioxidants known to man. It’s also one of the most powerful protectors of our cellular energy generators (our mitochondria) in existence.


How does that translate into meaningful effects? 

 

One study where male students ages 17 to 19 who took 4mg per day of astaxanthin for six months found that it improved their strength and endurance by an impressive 62 percent! Moreover, their endurance increased 300% faster than the control group! [7]

 

Obviously, if you’re looking for something to increase your energy levels, the implications of that are pretty obvious.

 

Astaxanthin is able to:

 

  • Protect mitochondria and support optimal cellular energy production [8-10]
  • Dramatically reduce inflammation [11] 
  • Increase blood flow [12]
  • Support heart health and reduce the oxidation of LDL [13]
  • Help modulate blood glucose [14]
  • Improve cognitive function [15]
  • Protect neurons from damage (and likely help prevent dementia and neurological disease) 
  • Decrease anxiety [16]
  • Decrease depression [17]
  • Decrease muscle inflammation by more than 50%
  • Improve physical endurance and exercise performance  [8, 9, 18, 19]
  • Increase muscle strength and mobility [20]
  • Act as an internal sunscreen and dramatically increase the skin’s tolerance to sun exposure [16, 21]
  • Improve the “heart-brain axis” (both mental and physical health) [22]
  • Improve energy levels [8, 23-27]

 

Importantly for our purposes here, astaxanthin is a very unique compound because it has the ability to penetrate inside of cells and actually incorporate itself inside of mitochondrial membranes, where it protects them from damage and supports energy production. [11, 28] Because of that, it is one of the most powerful ingredients for supporting mitochondrial health and energy levels.

 

Astaxanthin is a must-have energy and mitochondria-supporting compound that has literally dozens of positive side effects on everything from heart health, to brain health, to eye health, to skin health, to energy levels, and much more. It is one of nature’s most powerful health and energy-supporting nutrients. [29]


PQQ (Pyrroloquinoline Quinone)


Pyrroloquinoline quinone (PQQ) is one of the most powerful promoters of mitochondrial biogenesis ever discovered. [30, 31] Mitochondrial biogenesis is the process of your cells literally building more new mitochondria — cellular energy generators — from scratch. Since loss of mitochondria is one of the key drivers of fatigue (especially aging-associated fatigue), stimulating mitochondrial biogenesis is absolutely critical. And few things do it better than PQQ!


Interesting fact: PQQ is a growth factor in the human body, and our cells manufacture about 100-400 nanograms each day.


PQQ is a small quinone molecule which has the ability to be a REDOX agent, capable of reducing damaging oxidants (“free radicals”) that contribute to cellular and mitochondrial damage. It’s a remarkably powerful antioxidant — with some estimates being around 100 times more effective than vitamin C at eliminating free radicals. Via its actions as a REDOX agent in cells, it can modify signalling and supports mitochondrial function, which in turn can boost energy levels. [30-32]

 

But most importantly, it’s a powerful booster of mitochondrial growth and stimulator of mitochondrial biogenesis.

 

Studies have shown that PQQ can help with:

 

  • Decreasing systemic inflammation [33]
  • Improving sleep [34]
  • Improving brain function [35]
  • Speeding up metabolism, decreasing insulin resistance and increasing weight loss  [36, 37]
  • Improving immune function [38]
  • Improving mitochondrial health and stimulating mitochondrial biogenesis [30, 38]

Panax Ginseng


Panax ginseng is probably the single most powerful herbal/botanical compound for boosting energy levels. 

 

Panax Ginseng is commonly referred to as the 'True Ginseng' (being the most researched 'Ginseng' actually belonging to the plant family of 'Ginseng').


Panax Ginseng has proven benefits for: 


  • Increasing energy levels (decreasing fatigue)
  • Boosting mitochondrial health/function [39-44]
  • Mood optimization [45]
  • Improving immune function [46]
  • Anti-cancer effects [39]
  • Anti-inflammatory and anti-oxidant effects [39, 40]
  • Increased resistance to stress [39-41]
  • Improving brain function and cognition [47-50]

 

Let’s talk a bit more about the research on fatigue specifically…

 

One study in 52 people showed that a ginseng extract caused highly significant reductions in fatigue severity. [51]

 

Another study in 364 participants found that ginseng dramatically reduced cancer-related fatigue. [52]

 

Another placebo-controlled study in 90 people with chronic fatigue found that ginseng increased levels of internal antioxidants like glutathione, decreased oxidative stress, and reduced fatigue scores by about 30% in just 8 weeks. [53]

 

The researchers concluded “Taken together, these data lead us to conclude that P. ginseng can be used to combat chronic fatigue.” [53]

 

A review of 4 different studies with a total of over 400 healthy (non-fatigued) participants found significant increases in energy levels. [54]


Cordyceps


Cordyceps is a medicinal mushroom traditionally used in the east for thousands of years. It grows on the bodies of caterpillars, but is now more typically farmed (no caterpillars necessary). 

 

Cordyceps is perhaps the most prized energy booster within Eastern medicine traditions.


So it has long been known as an energizer and fatigue fighter, and importantly, modern research backs these traditional claims up.


Cordyceps has been proven to: 

 

  • Exert anti-aging effects at the cellular level [55]
  • Combat several types of cancer [56]
  • Boost immune function [57]
  • Fight inflammation [58]
  • Combat insulin resistance and type II diabetes [59]
  • Dramatically increase cellular energy production and improve exercise performance [60, 61]

Creatine Monohydrate


Creatine is among the most wellresearched, safe, and effective supplements for performance enhancement, especially activities involving short bursts of highintensity activity, but also even endurance exercise (cardio) to some extent.  [62-64]


It is proven to improve strength, increase lean muscle mass, and help the muscles recover more quickly during exercise. [64, 65]


Much less known by most people is that creatine also been shown to have neuroprotective and cardioprotective benefits and to improve brain function. [66-69]


In addition, it has been shown to increase both physical and mental energy in people with chronic fatigue syndrome. [70]

 

Creatine has also been shown to improve mitochondrial function. [66]

 

Overall, it’s one of the most evidence-backed supplements for physical energy enhancement — especially during physical activity.


D-Ribose


D-ribose is a special type of sugar that is required to create energy and DNA. [75] Some evidence suggests that D-ribose can help boost energy and physical function in situations where energy levels are reduced, such as people who have suffered from heart disease or stroke, or people engaging in regular intense exercise. [76-80]


D-ribose has been shown to dramatically improve energy levels in people with fibromyalgia or chronic fatigue syndrome by over 30%!  


There were also big improvements in sleep, well-being and decreased sensitivity to pain.

 

But that’s not the best part. The best part is that it accomplished this huge improvement in just three weeks! [81]

 

Another study reported similar findings after using 10 grams per day, with all benefits disappearing within a week of stopping supplementation. [82]


Coenzyme Q10


Coenzyme Q10 (CoQ10) is a molecule found in mitochondria that has a critical role in energy production. 


Several diseases and low-energy conditions are associated with low CoQ10 levels, including people who have fibromyalgia, [83-85] have survived heart attacks or heart failure, [86, 87] have multiple sclerosis, [88, 89] are infertile, [90-92] or suffer migraines. [93, 94] 


Generally speaking, CoQ10 will enhance blood flow, protect blood vessels, lower oxidative stress, and boost vitality in anyone who suffers from fatigue, but especially those people with the aforementioned conditions. 

 

Additionally, statin drugs are known to deplete CoQ10 levels, [95] so supplementation is mandatory in people taking a statin (even doctors know this and will co-prescribe CoQ10 with a statin). [96]



Curcumin


Curcumin is the yellow pigment and primary bioactive substance in turmeric. It possesses powerful anti-inflammatory and antioxidant properties that can help reduce depression and anxiety. [107, 108]

 

There is also evidence that curcumin can help slow cognitive decline with aging, promote cardiovascular health, reduce the risk of developing diabetes, and alleviate other inflammation-related conditions​. [109]


One of the key mechanisms by which it exerts these effects is through protecting and stabilizing mitochondrial membranes, and helping the body build more mitochondria from scratch (mitochondrial biogenesis). [110, 111]


Quercetin


Quercetin is a well-known bioflavonoid found in fruits and vegetables, particularly onions and apples. It is a potent antioxidant and anti-inflammatory molecule that affects an array of mitochondrial processes, including mitochondrial biogenesis, mitochondrial energy production, and the protection of mitochondria from oxidative stress. [113, 114]


It is also involved in helping the mitochondria to regenerate NAD+ — a key molecule that supports mitochondrial health and energy production.



Taurine


Taurine is a sulfur-containing amino acid essential for cardiovascular function and the development and function of skeletal muscle, the retina, and the brain. [115] It can help fight muscle loss with aging, [116] as well as benefit many other disease states, including neurodegenerative diseases, diseases of the eye, diabetes, heart failure, high blood pressure, and muscular dystrophies. [117]


Taurine is also essential for the proper function of mitochondria. [118, 119]



Magnesium


Magnesium is an essential dietary mineral, and the second most prevalent electrolyte in the human body. Magnesium deficiencies are common in developed countries because prominent sources of magnesium, like leafy vegetables, are not often eaten.  

 

A deficiency increases blood pressure, reduces glucose tolerance, and causes abnormal neural excitations that impair sleep. [120] It’s also a critical cofactor for mitochondrial energy production.


Energenesis provides two types of magnesium -- malate and citrate -- which provide other cofactors for mitochondrial energy production as well.



Acetyl-L-Carnitine


Acetyl L-Carnitine (ALCAR) is a unique form of L-Carnitine that has incredible brain- and body-boosting properties. 

 

Most importantly, it is one of the most evidence-backed anti-aging, and mitochondrial boosting (cellular energy-enhancing) compounds ever discovered.


ALCAR has been proven to: 

 

  • Reduces depression with a potency comparable to antidepressant drugs (with far less side effects) [121]
  • Protects and repairs neurons from damage (like that caused by diabetes) [122, 123]
  • Improves insulin sensitivity [124]
  • Improves cardiovascular health [125, 126]
  • Combats the side effects of aging, like neurological decline and chronic fatigue [127-131]
  • Increases mitochondrial function by increasing their ability to produce energy [132-134]

 

Notably, ALCAR has been known to cause fat loss, not because of any mechanism intrinsic to ALCAR, but simply because those taking it become more physically active due to the increased energy and vitality it provides.

 

Between powerful anti-depressant effects (likely even better than drugs like Prozac, but with far less side effects), general anti-aging/longevity benefits, brain protection, increased fat burning/weight loss, and increased energy levels, this is a must-have supplement.



Alpha-Lipoic Acid (ideally R-ALA)


Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism and the antioxidant system. [141] It provides a short but potent reduction of oxidation by increasing antioxidant enzymes, which protects against a variety of inflammatory and oxidative diseases like neurodegeneration. [142] ALA accumulates in various brain regions as soon as an hour after ingestion, [143, 144] and it has been shown to protect against neuronal cell death. [145]


ALA (especially R-ALA) is one of the most powerful evidence-backed compounds for mitochondrial repair and optimization.



Citrus Bioflavonoids (Hesperidin, Rutin, Naringenin)


Hesperidin is the primary bioactive compound in orange peels, alongside naringenin. They are powerful antioxidant and anti-inflammatory molecules, [148, 149] capable of protecting against several degenerative diseases and particularly brain diseases. [150] These effects are mediated, in part, by their ability to prevent mitochondrial dysfunction, to boost NAD+ and to combat oxidative stress. [151]



Green Tea Catechins


Green tea (Camellia Sinensis) catechins are four phytochemical molecules, the most potent one being epigallocatechin-3-gallate (EGCG). It has been implicated in benefiting almost every organ system in the body in doses you can obtain easily from simply drinking green tea. [152-154] EGCG is neuroprotective, [155,156] cardioprotective, [157, 158] anti-obesity, [159-161] anti-carcinogenic, [162, 163] anti-diabetic, [164] and an overall powerful protector of your mitochondria. [165-167]


In a 12-week double-blind trial published in the American Journal of Clinical Nutrition, researchers gave 38 overweight adults (ages 20 to 50) a daily polyphenol supplement or a placebo pill. The polyphenol supplement contained a mixture of EGCG (epigallocatechin-3-gallate, found in green tea) and resveratrol (which is also in Energenesis). People taking the polyphenol supplement had a highly significant increase in the function of mitochondria in their muscles compared to people given a placebo.


Cacao/Cocoa


Like green tea extract, cacao is packed with several powerful phytochemicals, including flavan3-ol and epicatechin. 

 

These catechins have wideranging health benefits, including everything from anti-aging effects in the skin, to boosting mood, to boosting mitochondrial energy production. 


It’s also one of the richest sources of PQQ, which is a powerful stimulator of mitochondrial biogenesis. (The base for Energenesis is made from cacao for this reason. Plus it tastes delicious!)


The unique phytochemical combination in cacao of epicatechin, flavan-3-ol, and PQQ likely have synergistic effects — making cacao an extremely potent concoction for energy and mitochondrial health.



B3 Variants (NMN, NR, Niacin & Niacinamide)


NAD+ has received a ton of attention in the last few years as possibly one of the most important compounds for anti-aging, disease prevention, prevention of DNA damage, and longevity. It also happens to be one of the most important compounds in regulating mitochondrial energy production.

 

Several studies have now found that boosting levels of NAD+ can have profound anti-aging effects, and can even “make old rats young again” (to steal some of the media headlines). [168-170]


This is where vitamin B3 (and versions of it, like niacin, niacinamide, nicotinamide riboside and nicotinamide mononucleotide) come in… They boost levels of NAD+. [171]

 

While much focus is now on nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), the best available research indicates that these extremely expensive ingredients may not be significantly superior to plain old niacin and niacinamide (which are far cheaper, and easier to take in larger quantities). In fact, some research suggests that NR and NMN actually get broken down in the digestive tract into niacinamide anyway. [168]


In other words, it likely does not make a whole lot of sense to spend exorbitant amounts of money on these fancy versions of niacin/niacinamide (NR or NMN) when they may actually be getting digested into niacinamide anyway before being absorbed into the bloodstream.

 

It is however, true that NAD+ is a critically important compound for promoting youthful mitochondrial function and energy production. All these B3 derivatives boost NAD+ levels significantly.


N-Acetyl Cysteine (NAC)


N-acetyl cysteine is special variant of the sulfur-rich amino acid cysteine.


It is actually a commonly used medicine in conventional medicine, in the context of acetaminophen (tylenol) toxicity – which is a commonly used drug that is also highly toxic to the liver (and depletes one of the body’s most important compounds for detoxification and antioxidant protection – glutathione). [172]


Why is NAC used for this purpose? Because it has a uniquely powerful ability to quickly rebuild healthy levels of glutathione.


NAC has been very thoroughly studied, with close to 1,000 clinical trials already done as of 2020. It has countless proven benefits:


  • Its antioxidant effects protect DNA [173]
  • It supports liver health and detoxification [172, 174]
  • Treating COPD and other respiratory symptoms
  • It boosts brain function and improves mental health [175, 176, 177]
  • Improves skin health
  • It improves mood (combats depression, and bipolar disorder) [175, 178]
  • Reduces fatigue after exercise [179]
  • It dramatically improves mitochondrial function (and protect the mitochondria from damage) [179-182]

Resveratrol (Ideally Trans-Resveratrol)


Resveratrol is a beneficial compound found in red wine that is associated with life extension. It is produced in grape skins as a defense against insects. 

 

The primary way it works to exert its energy- and longevity-boosting effects is through a compound called SIRT1 and another called NAD+. Together, these two compounds are part of our most important anti-aging, mitochondria-boosting and longevity circuit. 


When the body is under stress and chronic inflammation/oxidative stress, certain cellular proteins (things like enzymes, and even DNA) get acetylated — an acetyl gets added to them. This essentially damages the structure and function of these important cellular proteins (that may be involved with key cellular processes, for example, in producing energy).

 

SIRT1 is a sort of a pac-man enzyme that “chews” off acetyl groups from other proteins (including DNA). By getting rid of the acetyl groups, it allows these proteins to still function optimally and can even help prevent and repair damage to genes. Think of it like bringing your cellular proteins, enzymes and DNA back into the state when you were young.

 

  • De-acetylated proteins = young proteins
  • Acetylated proteins = old proteins

 

So again, SIRT1 basically helps turn older proteins into younger proteins. SIRT1 has been recognized to help protect against age-related diseases, such as cardiovascular disease, cancer, and neurodegeneration.

 

So where does resveratrol come in?

 

Resveratrol is direct booster of this SIRT1 pathway, and boosts NAD+ — which is like the accelerator pedal for the SIRT1 pathway.

 

It is a potent booster of our mitochondria and internal antioxidant defense system [184, 185] and is proven to have all sorts of incredible anti-aging effects, like:

 

  • Activating longevity genes [111, 185, 186]
  • Stimulating mitochondrial biogenesis [111, 185]
  • Increasing levels of NAD+ (a key energy, longevity and anti-aging compound) [187, 188]
  • Protecting against heart disease [111, 185, 186, 189]
  • Combating insulin resistance [190]
  • Increasing blood flow (and oxygen and nutrient delivery) to the brain [189]
  • Fighting senescent cells (immortal cells that produce inflammatory compounds that are one of the main mechanisms of aging)
  • Activating autophagy (another key pathway of longevity) [111, 185]
  • Improving immune function [191, 192]
  • Fighting oxidative stress and inflammation [191, 192, 193]
  • Combating/preventing cancer [189]
  • Mood-boosting and antidepressant effects [187, 194]
  • Improving physical energy, stamina and endurance [187, 195-198]

 

Moreover, unlike other antioxidants that interfere with exercise-induced adaptations, [199] like muscle protein synthesis and mitochondrial biogenesis, resveratrol appears to enhance the physiological benefits of exercise. [196, 197] In fact, research shows that in animals, it DOUBLES the time it takes for animals to run to the point of exhaustion (i.e. they had energy for much longer than animals not taking resveratrol.)

Get Your Energenesis Now!

Energenesis is currently sold out. Our next batch arrives in 4-6 weeks.

Purchasing now will ensure it is shipped to you as soon as it is in stock.

FREE shipping inside US
We send internationally!

(For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.)


What people say about Energenesis

Get Your Energenesis Now!

Energenesis is currently sold out. Our next batch arrives in 4-6 weeks.

Purchasing now will ensure it is shipped to you as soon as it is in stock.

FREE shipping inside US
We send internationally!

(For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.)


Introducing The Most Powerful

Mitochondria and Energy Support Supplement Ever Created – Energenesis


I’m excited to announce that after nearly 2 years of development, my team and I have developed the most powerful mitochondrial energy supplement ever developed. 

 

I say this definitively, because once you see the list of ingredients in this (it includes almost all the ingredients mentioned in the list above) and the fact that it has REAL effective doses of these ingredients (which no other manufacturer is doing), you’re going to be blown away…

Energenesis is the most powerful mitochondria-enhancing nutraceutical ever created!

  

Energenesis is the first non-stimulant energy formula that actually builds up your own body’s ability to produce energy!

 

Packed with a potent dose of a whopping 23 of the most powerful mitochondria-building ingredients in existence, Energenesis is a NEW, premium, scientifically-backed formula to re-awaken your body’s built-in energy system. 

 

What makes Energenesis different? 

 

Unlike previous generation “energy supplements,” it contains no stimulants, no caffeine, and no sugar. This isn’t about giving you a fake energy boost, while actually making your energy levels worse over time. 

 

Energenesis builds REAL ENERGY!

 

This is not a supplement designed to fill to people’s desire for quick fixes and instant gratification through stimulants and temporary boosts of fake energy. 


Energenesis is for people looking for REAL ANSWERS, who want to address ROOT CAUSES, and want to build real energy at the cellular level. 

 

As a result, the energy your mitochondria produce naturally decreases over time, reducing your health and longevity — and ultimately, causing fatigue.

 

On top of that, stressors in our life — from psychological stress, to environmental toxins (like heavy metals and air pollutants), to a poor diet, to poor gut health, to chronic inflammation — all cause mitochondrial damage, dysfunction and shut down (they shift out of energy mode into a cell protection response). 

 

Research is now showing that these three things — the loss of mitochondria, the damage/dysfunction of mitochondria, and the shut down of mitochondria — are the primary factors that drive low energy levels.

 

In other words, if you’ve got low energy levels, it likely simply means that your mitochondria have become weak, damaged, dysfunctional, and switched off over time. 

 

Here’s the spectrum of energy, so you can visualize where you are on this continuum. 

As you take Energenesis consistently over several weeks, it builds up your cellular engine, your mitochondria. 

 

You may feel a slight energy boost from the very first time you take it, but what it’s really doing is steadily and sustainably re-charging and building up your mitochondria so that your body becomes capable of producing more energy on its own! 

 

In short, Energenesis is a repair system for the natural process of dysfunctional energy producing cells. It acts by restoring your body’s ability to rely on itself for energy.

 

The old way to make an energy supplement was just about using caffeine, sugar and other stimulants to give a quick jolt. (While actually making you worse over time.) 

 

We’re here to introduce the NEW way to make an energy supplement – by using the science of how to actually build up the body’s own production of cellular energy! 

​Get Your Own Bottle Of Energenesis!

Energenesis is currently sold out. Our next batch arrives in 4-6 weeks.

Purchasing now will ensure it is shipped to you as soon as it is in stock.

FREE shipping inside US
We send internationally!

(For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.)


Energenesis is a next generation energy supplement


Remember the 6 key mechanisms you need to support optimal mitochondrial health.


  1. You Need BIGGER Mitochondria
  2. You Need MORE Mitochondria (i.e. Mitochondrial Biogenesis)
  3. It’s VITAL to Repair and Protect Your Mitochondrial Membranes 
  4. You Need Cofactors Involved Mitochondria Energy Production
  5. You Need To Recharge NAD+ Levels
  6. You Need To Build Up Your Mitochondrial Internal Defense System


This is EXACTLY what Energenesis is designed to do!


What's In Energenesis? 


Energenesis is loaded with 23 of the most potent mitochondria-building ingredients in existence.

Energenesis is like a 5-star MEAL for your Mitochondria (LOADED with rare nutrients, energy boosters and powerful antioxidants, because your body needs a variety - each one works differently!) AND… we have gone to amazing lengths to source the highest quality ingredients, with unparalleled potency, purity, biological availability, and effectiveness…

 

If you want to see a breakdown of the exact ingredients and amounts, you can look in the right column of the image below...

It’s a potent cocktail of the most powerful mitochondrial regenerating ingredients designed to literally CHARGE your cells back up, so you can have the energy you had when you were young – ALL DAY ENERGY.

 

If you’ve been struggling with fatigue or low energy levels, it’s time to stop dragging yourself through the day with caffeine and stimulants…  

 

It’s time to start building REAL ENERGY.  

 

You can certainly use the information here to go out and buy all these compounds as separate supplements, but I strongly encourage you to simply get Energenesis. It’s obviously far more convenient to get everything in one formula rather than fiddling with 20 different bottles and 25 pills each day. Also, you don’t have to worry about dosing everything correctly.


And, on top of that, I’ve tried to make it a complete no brainer for you by making it way cheaper for you to order it this way (as opposed to buying 20+ different supplements).

 

Energenesis is simply the most powerful formula ever developed for that purpose.

 

We have it available in either 1, 3 or 5 bottle packages (obviously, the more you order, the cheaper it gets).

Get Your Energenesis Now!

Energenesis is currently sold out. Our next batch arrives in 4-6 weeks.

Purchasing now will ensure it is shipped to you as soon as it is in stock.

FREE shipping inside US
We send internationally!

(For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.)

What people say about Energenesis

Energenesis is designed to


Supercharge Your Mitochondria

Decrease Brain Fog, and Improve Brain Energy, Focus, And Memory

Enhance Your Endurance And Stamina

Improve Mood

Increase Your Physical Energy Levels

Get Energenesis Now!

Energenesis is currently sold out. Our next batch arrives in 4-6 weeks.

Purchasing now will ensure it is shipped to you as soon as it is in stock.

FREE shipping inside US
We send internationally!

(For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid. Buyer is responsible for delivery fees.)


References

1. Nicolson, G. L. & Ash, M. E. Lipid Replacement Therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function. Biochim. Biophys. Acta 1838, 1657–1679 (2014).

2. Nicolson, G. L. & Ellithorpe, R. Lipid Replacement and Antioxidant Nutritional Therapy for Restoring Mitochondrial Function and Reducing Fatigue in Chronic Fatigue Syndrome and Other Fatiguing Illnesses. J. Chronic Fatigue Syndr. 13, 57–68 (2006).

3. L. Nicolson, G., Settineri, R. & Ellithorpe, R. Lipid Replacement Therapy with a Glycophospholipid

Formulation with NADH and CoQ10 Significantly Reduces Fatigue in Intractable Chronic Fatiguing Illnesses and Chronic Lyme Disease Patients. IJCM 03, 163–170 (2012).

4. Agadjanyan, M. et al. Nutritional Supplement (NT FactorTM) Restores Mitochondrial Function and Reduces Moderately Severe Fatigue in Aged Subjects. J. Chronic Fatigue Syndr. 11, 23–36 (2003).

5. Nicolson, G. L. & Conklin, K. A. Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by molecular replacement therapy. Clin. Exp. Metastasis 25, 161– 169 (2008).

6. Nicolson, G. L. Lipid replacement/antioxidant therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function. Pathol. Oncol. Res. 11, 139–144 (2005).

7. Malmsten, C., et al., Dietary Supplementation with Astaxanthin-Rich Algal Meal Improves Strength Endurance

8. Kidd, P., Astaxanthin, Cell Membrane Nutrient with Diverse Clinical Benefits and Anti-Aging Potential

9. Daniells, S, (2015) Astaxanthin may extend endurance by boosting mitochondrial action 

10. Yu, T., Dohl, J., Chen, Y., Gasier, H. G. & Deuster, P. A. Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat‐induced skeletal muscle injury. Journal of Cellular Physiology vol. 234 13292–13302 (2019).

11. The power of natural astaxanthin for increased muscle performance.  

12. Pashkow, F. J., Watumull, D. G. & Campbell, C. L. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Am. J. Cardiol. 101, 58D–68D (2008).

13. Goulinet, S. & Chapman, M. J. Plasma LDL and HDL subspecies are heterogenous in particle content of tocopherols and oxygenated and hydrocarbon carotenoids. Relevance to oxidative resistance and atherogenesis. Arterioscler. Thromb. Vasc. Biol. 17, 786–796 (1997).

14. Mashhadi, N. S. et al. Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus. Asia Pac. J. Clin. Nutr. 27, 341–346 (2018).

15. Ito, N., Saito, H., Seki, S., Ueda, F. & Asada, T. Effects of Composite Supplement Containing Astaxanthin and Sesamin on Cognitive Functions in People with Mild Cognitive Impairment: A Randomized, DoubleBlind, Placebo-Controlled Trial. J. Alzheimers. Dis. 62, 1767–1775 (2018).

16. Nishioka, Y. et al. The antianxiety-like effect of astaxanthin extracted from Paracoccus carotinifaciens. Biofactors 37, 25–30 (2011).

17. Thalbott, S., et al., (2019) Astaxanthin Supplementation Reduces Depression and Fatigue in Healthy Subjects

18. Earnest, C. P., Lupo, M., White, K. M. & Church, T. S. Effect of astaxanthin on cycling time trial performance. Int. J. Sports Med. 32, 882–888 (2011).

19. Polotow, T. G. et al. Astaxanthin Supplementation Delays Physical Exhaustion and Prevents Redox Imbalances in Plasma and Soleus Muscles of Wistar Rats. Nutrients 6, 5819 (2014).

20. Liu, S. Z. et al. Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly. J. Cachexia Sarcopenia Muscle 9, 826–833 (2018).

21. Ito, N., Seki, S. & Ueda, F. The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People—A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients vol. 10 817 (2018).

22. Talbott, S. M. et al. Effect of Astaxanthin Supplementation on Psychophysiological Heart-Brain Axis Dynamics in Healthy Subjects. Functional Foods in Health and Disease vol. 9 521 (2019).

23. Malmsten, C., et al., Dietary Supplementation with Astaxanthin-Rich Algal Meal Improves Strength Endurance

24. Capelli, B., et.al. (2016) The Anti-Aging Benefits of Astaxanthin and How it Can Protect our Cells and DNA

25. New study shows Astaxanthin is effective against daily mental and physical fatigue 

26. pubmeddev & Imai A, E. al. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover S... - PubMed - NCBI.  

27. Clinical study shows AstaReal® astaxanthin effective in reducing both mental and physical fatigue - AstaReal.  

28. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J. Nutr. Biochem. 21, 381–389 (2010).

29. Capelli, B., et.al. (2016) The Anti-Aging Benefits of Astaxanthin and How it Can Protect our Cells and DNA .

30. Chowanadisai, W. et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J. Biol. Chem. 285, 142–152 (2010).

31. Hwang, P. & Willoughby, D. S. Mechanisms Behind Pyrroloquinoline Quinone Supplementation on Skeletal Muscle Mitochondrial Biogenesis: Possible Synergistic Effects with Exercise. J. Am. Coll. Nutr. 1– 11 (2018).

32. Harris, C. B. et al. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J. Nutr. Biochem. 24, 2076–2084 (2013).

33. pubmeddev & Harris CB, E. al. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. - PubMed - NCBI.  

34. Nakano, M., Yamamoto, T., Okamura, H., Tsuda, A. & Kowatari, Y. Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep. Functional Foods in Health and Disease 2, 307– 324 (2012).

35. pubmeddev & Takatsu H, E. al. Effect of vitamin E on learning and memory deficit in aged rats. - PubMed - NCBI.  

36. pubmeddev & Bauerly K, E. al. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. - PubMed - NCBI.  

37. pubmeddev & Muoio D M And. Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease. - PubMed - NCBI.  

38. pubmeddev & Steinberg F, E. al. Pyrroloquinoline quinone improves growth and reproductive performance in mice fed chemically defined diets. - PubMed - NCBI.  

39. pubmeddev & Jin X, E. al. Ginseng consumption and risk of cancer: A meta-analysis. - PubMed - NCBI.  

40. Kim, J. Y., Park, J. Y., Kang, H. J., Kim, O. Y. & Lee, J. H. Beneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebo-controlled trial. Nutr. J. 11, 47 (2012).

41. pubmeddev & Nocerino E, E. al. The aphrodisiac and adaptogenic properties of ginseng. - PubMed - NCBI.

https://www.ncbi.nlm.nih.gov/pubmed/10930706.

42. pubmeddev & Chanana P And Kumar. GABA-BZD Receptor Modulating Mechanism of Panax quinquefolius against 72-h Sleep Deprivation Induced Anxiety like Behavior: Possible Roles of Oxida... - PubMed - NCBI. 

43. Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson’s disease. J. Ethnopharmacol. 247, 112213 (2020).

44. pubmeddev & Dong GZ, E. al. Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway. - PubMed - NCBI.  .

45. pubmeddev & Wiklund IK, E. al. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, plac... - PubMed - NCBI.  

46. pubmeddev & Scaglione F, E. al. Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the... - PubMed - NCBI.  

47. Coleman, C. I., Hebert, J. H. & Reddy, P. The effects of Panax ginseng on quality of life. J. Clin. Pharm. Ther. 28, 5–15 (2003).

48. Kim, J.-H. Pharmacological and medical applications of and ginsenosides: a review for use in cardiovascular diseases. J. Ginseng Res. 42, 264–269 (2018).

49. Lee, S.-T., Chu, K., Sim, J.-Y., Heo, J.-H. & Kim, M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 22, 222–226 (2008).

50. Lho, S. K. et al. Effects of lifetime cumulative ginseng intake on cognitive function in late life. Alzheimers. Res. Ther. 10, 50 (2018).

51. pubmeddev & Lee N, E. al. Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled Trial. - PubMed - NCBI.

https://www.ncbi.nlm.nih.gov/pubmed/27754709.

52. Barton, D. L. et al. Wisconsin Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind Trial, N07C2. JNCI Journal of the National Cancer Institute 105, 1230 (2013).

53. Kim, H.-G. et al. Antifatigue Effects of Panax ginseng C.A. Meyer: A Randomised, Double-Blind, PlaceboControlled Trial. PLoS One 8, (2013).

54. Bach, H. V., Kim, J., Myung, S.-K. & Cho, Y. A. Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis. J. Korean Med. Sci. 31, 1879 (2016).

55. [No title]. https://www.fasebj.org/doi/abs/10.1096/fasebj.25.1_supplement.599.192758/.

56. Ng, T. B. & Wang, H. X. Pharmacological actions of Cordyceps, a prized folk medicine. J. Pharm. Pharmacol. 57, 1509–1519 (2005).

57. Lin, B.-Q. & Li, S.-P. Cordyceps as an Herbal Drug. in Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition (CRC Press/Taylor & Francis, 2011).

58. pubmeddev & Kuo YC, E. al. Cordyceps sinensis as an immunomodulatory agent. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/8874668.

59. pubmeddev & Lo HC, E. al. The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin. - PubMed - NCBI.    

61. Hirsch, K. R., Smith-Ryan, A. E., Roelofs, E. J., Trexler, E. T. & Mock, M. G. Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation. J. Diet. Suppl. 14, 42 (2017).

62. Bird, S. P. Creatine supplementation and exercise performance: a brief review. J. Sports Sci. Med. 2, 123– 132 (2003).

63. Jagim, A. R., Stecker, R. A., Harty, P. S., Erickson, J. L. & Kerksick, C. M. Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review. Front Nutr 5, 115 (2018).

64. Vukovich, M. D. & Peeters, B. M. EFFECTS OF CREATINE SUPPLEMENTATION ON EXERCISE PERFORMANCE: A META-ANALYTICAL REVIEW. Medicine & Science in Sports & Exercise vol. 31 S263 (1999).

65. Chilibeck, P. D., Kaviani, M., Candow, D. G. & Zello, G. A. Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis. Open Access J Sports Med 8, 213–226 (2017).

66. Barbieri, E. et al. Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity. Oxidative Medicine and Cellular Longevity vol. 2016 1–12 (2016).

67. Avgerinos, K. I., Spyrou, N., Bougioukas, K. I. & Kapogiannis, D. Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Exp. Gerontol. 108, 166–173 (2018).

68. Rawson, E. S. & Venezia, A. C. Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Amino Acids 40, 1349–1362 (2011).

69. Korpacheva, O. V., Dolgikh, V. T., Shikunova, L. G. & Zolotov, A. N. [Cardioprotective effect of exogenous creatine phosphate in acute hemorrhage]. Anesteziol. Reanimatol. 13–16 (2002).

70. Study links nutritional supplement, creatine, to increased metabolic energy. EurekAlert!  

71. Bondonno, C. P., Croft, K. D. & Hodgson, J. M. Dietary Nitrate, Nitric Oxide, and Cardiovascular Health. Crit. Rev. Food Sci. Nutr. 56, 2036–2052 (2016).

72. Bondonno, C. P. et al. Vegetable-derived bioactive nitrate and cardiovascular health. Mol. Aspects Med. 61, 83–91 (2018).

73. Stanaway, L., Rutherfurd-Markwick, K., Page, R. & Ali, A. Performance and Health Benefits of Dietary Nitrate Supplementation in Older Adults: A Systematic Review. Nutrients 9, (2017).

74. Jones, A. M., Thompson, C., Wylie, L. J. & Vanhatalo, A. Dietary Nitrate and Physical Performance. Annu. Rev. Nutr. 38, 303–328 (2018).

75. Mahoney, D. E. et al. Understanding D-Ribose and Mitochondrial Function. Adv Biosci Clin Med 6, 1–5 (2018).

76. Omran, H., Illien, S., MacCarter, D., St Cyr, J. & Lüderitz, B. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur. J. Heart Fail. 5, 615– 619 (2003).

77. MacCarter, D. et al. D-ribose aids advanced ischemic heart failure patients. Int. J. Cardiol. 137, 79–80 (2009).

78. Pliml, W. et al. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet 340, 507–510 (1992).

79. Hellsten, Y., Skadhauge, L. & Bangsbo, J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R182–8 (2004).

80. Seifert, J. G., Brumet, A. & St Cyr, J. A. The influence of D-ribose ingestion and fitness level on performance and recovery. J. Int. Soc. Sports Nutr. 14, 47 (2017).

81. Teitelbaum, J. E., Johnson, C. & St Cyr, J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J. Altern. Complement. Med. 12, 857–862 (2006).

82. Gebhart, B. & Jorgenson, J. A. Benefit of ribose in a patient with fibromyalgia. Pharmacotherapy 24, 1646–1648 (2004).

83. Cordero, M. D. et al. Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia. Clin. Biochem. 42, 732–735 (2009).

84. Di Pierro, F., Rossi, A., Consensi, A., Giacomelli, C. & Bazzichi, L. Role for a water-soluble form of CoQ10 in female subjects affected by fibromyalgia. A preliminary study. Clin. Exp. Rheumatol. 35 Suppl 105, 20–27 (2017).

85. Cordero, M. D. et al. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Antioxid. Redox Signal. 19, 1356–1361 (2013).

86. Jafari, M., Mousavi, S. M., Asgharzadeh, A. & Yazdani, N. Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews. Indian Heart J. 70 Suppl 1, S111–S117 (2018).

87. DiNicolantonio, J. J., Bhutani, J., McCarty, M. F. & O’Keefe, J. H. Coenzyme Q10 for the treatment of heart failure: a review of the literature. Open Heart 2, e000326 (2015).

88. Sanoobar, M., Dehghan, P., Khalili, M., Azimi, A. & Seifar, F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial. Nutr. Neurosci. 19, 138– 143 (2016).

89. Sanoobar, M. et al. Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial. Nutr. Neurosci. 18, 169– 176 (2015).

90. Lafuente, R. et al. Coenzyme Q10 and male infertility: a meta-analysis. J. Assist. Reprod. Genet. 30, 1147– 1156 (2013).

91. Xu, Y. et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in lowprognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod. Biol. Endocrinol. 16, 29 (2018).

92. Ben-Meir, A. et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell 14, 887–895 (2015).

93. Shoeibi, A. et al. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurol. Belg. 117, 103–109 (2017).

94. Sándor, P. S. et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 64, 713–715 (2005).

95. Deichmann, R., Lavie, C. & Andrews, S. Coenzyme q10 and statin-induced mitochondrial dysfunction. Ochsner J. 10, 16–21 (2010).

96. Skarlovnik, A., Janić, M., Lunder, M., Turk, M. & Šabovič, M. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Med. Sci. Monit. 20, 2183–2188 (2014).

97. Kasper, S. & Dienel, A. Multicenter, open-label, exploratory clinical trial with extract in patients suffering from burnout symptoms. Neuropsychiatr. Dis. Treat. 13, 889–898 (2017).

98. Anghelescu, I.-G., Edwards, D., Seifritz, E. & Kasper, S. Stress management and the role of Rhodiola rosea: a review. Int. J. Psychiatry Clin. Pract. 1–11 (2018).

99. McCarty, M. F. Clinical potential of Spirulina as a source of phycocyanobilin. J. Med. Food 10, 566–570 (2007).

100. Nawrocka, D., Kornicka, K., Śmieszek, A. & Marycz, K. Spirulina platensis Improves Mitochondrial Function Impaired by Elevated Oxidative Stress in Adipose-Derived Mesenchymal Stromal Cells (ASCs) and Intestinal Epithelial Cells (IECs), and Enhances Insulin Sensitivity in Equine Metabolic Syndrome (EMS) Horses. Mar. Drugs 15, (2017).

101. Zheng, J. et al. Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304, R110–20 (2013).

102. Saha, S. K., Misbahuddin, M., Khatun, R. & Mamun, I. R. Effect of hexane extract of spirulina in the removal of arsenic from isolated liver tissues of rat. Mymensingh Med. J. 14, 191–195 (2005).

103. Saha, S. K., Misbahuddin, M. & Ahmed, A. U. Comparison between the effects of alcohol and hexane extract of spirulina in arsenic removal from isolated tissues. Mymensingh Med. J. 19, 27–31 (2010).

104. pubmeddev & Wu LC, E. al. Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/15884862.

105. pubmeddev & Johnson M, E. al. A randomized, double blind, placebo controlled study of spirulina supplementation on indices of mental and physical fatigue in men. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/26888417.

106. pubmeddev & Kalafati M, E. al. Ergogenic and antioxidant effects of spirulina supplementation in humans. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/20010119.

107. Ng, Q. X., Koh, S. S. H., Chan, H. W. & Ho, C. Y. X. Clinical Use of Curcumin in Depression: A Meta-Analysis. J. Am. Med. Dir. Assoc. 18, 503–508 (2017).

108. Noorafshan, A., Vafabin, M., Karbalay-Doust, S. & Asadi-Golshan, R. Efficacy of Curcumin in the Modulation of Anxiety Provoked by Sulfite, a Food Preservative, in Rats. Prev Nutr Food Sci 22, 144–148 (2017).

109. Hewlings, S. J. & Kalman, D. S. Curcumin: A Review of Its’ Effects on Human Health. Foods 6, (2017).

110. Soto-Urquieta, M. G. et al. Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice. Biol. Res. 47, 74 (2014).

111. Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs. Biotechnol. Adv. 34, 813–826 (2016).

112. Jamwal, R. Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers. J. Integr. Med. 16, 367–374 (2018).

113. de Oliveira, M. R. et al. Quercetin and the mitochondria: A mechanistic view. Biotechnol. Adv. 34, 532– 549 (2016).

114. Davis, J. M., Murphy, E. A., Carmichael, M. D. & Davis, B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296, R1071– 7 (2009).

115. Ripps, H. & Shen, W. Review: taurine: a ‘very essential’ amino acid. Mol. Vis. 18, 2673–2686 (2012).

116. Scicchitano, B. M. & Sica, G. The Beneficial Effects of Taurine to Counteract Sarcopenia. Curr. Protein Pept. Sci. 19, 673–680 (2018).

117. Schaffer, S. & Kim, H. W. Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomol. Ther.  26, 225–241 (2018).

118. Jong, C. J., Ito, T., Prentice, H., Wu, J.-Y. & Schaffer, S. W. Role of Mitochondria and Endoplasmic Reticulum in Taurine-Deficiency-Mediated Apoptosis. Nutrients 9, (2017).

119. Hansen, S. H., Andersen, M. L., Cornett, C., Gradinaru, R. & Grunnet, N. A role for taurine in mitochondrial function. J. Biomed. Sci. 17 Suppl 1, S23 (2010).

120. Schwalfenberg, G. K. & Genuis, S. J. The Importance of Magnesium in Clinical Healthcare. Scientifica  2017, 4179326 (2017).

121. Veronese, N. et al. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom. Med. 80, 154–159 (2018).

122. Rump, T. J. et al. Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. Free Radic. Biol. Med. 49, 1494–1504 (2010).

123. Scafidi, S., Racz, J., Hazelton, J., McKenna, M. C. & Fiskum, G. Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain. Dev. Neurosci. 32, 480–487 (2010).

124. Xu, Y. et al. L-carnitine treatment of insulin resistance: A systematic review and meta-analysis. Adv. Clin. Exp. Med. 26, 333–338 (2017).

125. Song, X. et al. Efficacy and Safety of L-Carnitine Treatment for Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials. Biomed Res. Int. 2017, 6274854 (2017).

126. Shang, R., Sun, Z. & Li, H. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis. BMC Cardiovasc. Disord. 14, 88 (2014).

127. Rai, G. et al. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer’s dementia. Curr. Med. Res. Opin. 11, 638–647 (1990).

128. Passeri, M. et al. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Int. J. Clin. Pharmacol. Res. 10, 75–79 (1990).

129. Thal, L. J. et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer’s disease. Neurology 47, 705–711 (1996).

130. Tomassini, V. et al. Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. J. Neurol. Sci. 218, 103–108 (2004).

131. Plioplys, A. V. & Plioplys, S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology 35, 16–23 (1997).

132. Nicassio, L. et al. Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. Exp. Gerontol. 98, 99– 109 (2017).

133. Patel, S. P., Sullivan, P. G., Lyttle, T. S. & Rabchevsky, A. G. Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. J. Neurochem. 114, 291–301 (2010).

134. Rosca, M. G., Lemieux, H. & Hoppel, C. L. Mitochondria in the elderly: Is acetylcarnitine a rejuvenator? Adv. Drug Deliv. Rev. 61, 1332–1342 (2009).

135. Carrasco-Gallardo, C., Guzmán, L. & Maccioni, R. B. Shilajit: a natural phytocomplex with potential procognitive activity. Int. J. Alzheimers. Dis. 2012, 674142 (2012).

136. Surapaneni, D. K. et al. Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats. J. Ethnopharmacol. 143, 91–99 (2012).

137. Heber, D. Pomegranate Ellagitannins. in Herbal Medicine: Biomolecular and Clinical Aspects (eds. Benzie, I. F. F. & Wachtel-Galor, S.) (CRC Press/Taylor & Francis, 2012).

138. Ismail, T. et al. Ellagitannins in Cancer Chemoprevention and Therapy. Toxins  8, (2016).

139. Rodriguez, J. et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J. Cachexia Sarcopenia Muscle 8, 583–597 (2017).

140. Zhao, W. et al. Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells. Mol. Carcinog. 57, 193–200 (2018).

141. Shay, K. P., Moreau, R. F., Smith, E. J., Smith, A. R. & Hagen, T. M. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim. Biophys. Acta 1790, 1149–1160 (2009).

142. Poon, H. F. et al. Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alphalipoic acid: implications for aging and age-related neurodegenerative disorders. Neurochem. Int. 46, 159– 168 (2005).

143. Panigrahi, M. et al. alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 717, 184–188 (1996).

144. Arivazhagan, P., Shila, S., Kumaran, S. & Panneerselvam, C. Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats. Exp. Gerontol. 37, 803– 811 (2002).

145. Zhang, L. et al. Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway. Neurosci. Lett. 312, 125–128 (2001).

146. Breithaupt-Grögler, K. et al. Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. Eur. J. Pharm. Sci. 8, 57–65 (1999).

147. Freisleben, H. J., Neeb, A., Lehr, F. & Ackermann, H. Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice. Arzneimittelforschung 47, 776–780 (1997).

148. Tejada, S. et al. Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus. Curr. Med. Chem. 25, 4929–4945 (2018).

149. Manchope, M. F., Casagrande, R. & Verri, W. A., Jr. Naringenin: an analgesic and anti-inflammatory citrus flavanone. Oncotarget 8, 3766–3767 (2017).

150. Benavente-García, O. & Castillo, J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem. 56, 6185–6205 (2008).

151. Kumar, A., Prakash, A. & Dogra, S. Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. Food Chem. Toxicol. 48, 626–632 (2010).

152. Singhal, K., Raj, N., Gupta, K. & Singh, S. Probable benefits of green tea with genetic implications. J. Oral Maxillofac. Pathol. 21, 107–114 (2017).

153. Suzuki, Y., Miyoshi, N. & Isemura, M. Health-promoting effects of green tea. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 88, 88–101 (2012).

154. Chacko, S. M., Thambi, P. T., Kuttan, R. & Nishigaki, I. Beneficial effects of green tea: a literature review. Chin. Med. 5, 13 (2010).

155. Ortiz-López, L. et al. Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro. Neuroscience 322, 208–220 (2016).

156. Pervin, M. et al. Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases. Molecules 23, (2018).

157. Babu, P. V. A. & Liu, D. Green tea catechins and cardiovascular health: an update. Curr. Med. Chem. 15, 1840–1850 (2008).

158. Bhardwaj, P. & Khanna, D. Green tea catechins: defensive role in cardiovascular disorders. Chin. J. Nat. Med. 11, 345–353 (2013).

159. Rains, T. M., Agarwal, S. & Maki, K. C. Antiobesity effects of green tea catechins: a mechanistic review. J. Nutr. Biochem. 22, 1–7 (2011).

160. Hursel, R. & Westerterp-Plantenga, M. S. Catechin- and caffeine-rich teas for control of body weight in humans. Am. J. Clin. Nutr. 98, 1682S–1693S (2013).

161. Hursel, R., Viechtbauer, W. & Westerterp-Plantenga, M. S. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int. J. Obes.  33, 956–961 (2009).

162. Cooper, R., Morré, D. J. & Morré, D. M. Medicinal benefits of green tea: part II. review of anticancer properties. J. Altern. Complement. Med. 11, 639–652 (2005).

163. Lambert, J. D. Does tea prevent cancer? Evidence from laboratory and human intervention studies. Am. J. Clin. Nutr. 98, 1667S–1675S (2013).

164. Park, J.-H., Bae, J.-H., Im, S.-S. & Song, D.-K. Green tea and type 2 diabetes. Integr Med Res 3, 4–10 (2014).

165. Forester, S. C. & Lambert, J. D. The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Mol. Nutr. Food Res. 55, 844–854 (2011).

166. Ohishi, T., Goto, S., Monira, P., Isemura, M. & Nakamura, Y. Anti-inflammatory Action of Green Tea. Antiinflamm. Antiallergy Agents Med. Chem. 15, 74–90 (2016).

167. Bernatoniene, J. & Kopustinskiene, D. M. The Role of Catechins in Cellular Responses to Oxidative Stress. Molecules 23, (2018).

168. Greg Kelly. ND, (2019) NAD: INTRODUCTION TO AN IMPORTANT HEALTHSPAN MOLECULE

169. Klimova, B., Novotny, M. & Kuca, K. Anti-Aging Drugs - Prospect of Longer Life? Curr. Med. Chem. 25, 1946–1953 (2018).

170. Park, A. Scientists Can Reverse DNA Aging in Mice. Time https://time.com/4711023/how-to-keep-yourdna-from-aging/ (2017).

171. Dölle, C., Skoge, R. H., Vanlinden, M. R. & Ziegler, M. NAD biosynthesis in humans--enzymes, metabolites and therapeutic aspects. Curr. Top. Med. Chem. 13, 2907–2917 (2013).

172. pubmeddev & de Andrade KQ, E. al. Oxidative Stress and Inflammation in Hepatic Diseases:

Therapeutic Possibilities of N-Acetylcysteine. - PubMed - NCBI.

https://www.ncbi.nlm.nih.gov/pubmed/26694382.

173. pubmeddev & Rushworth G F And. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. - PubMed - NCBI.

https://www.ncbi.nlm.nih.gov/pubmed/24080471.

174. pubmeddev & Elbini Dhouib I, E. al. A minireview on N-acetylcysteine: An old drug with new approaches. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/26946308.

175. pubmeddev & Fernandes BS, E. al. N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis. - PubMed - NCBI.

https://www.ncbi.nlm.nih.gov/pubmed/27137430.

176. pubmeddev & Afshar H, E. al. N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial. - PubMed - NCBI.

https://www.ncbi.nlm.nih.gov/pubmed/23131885.

177. pubmeddev & Hardan AY, E. al. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/22342106.

178. pubmeddev & Magalhães PV, E. al. N-acetylcysteine for major depressive episodes in bipolar disorder. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/22189927.

179. pubmeddev & Kelly MK, E. al. Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/18992854.

180. Fries, G. R. & Kapczinski, F. N-acetylcysteine as a mitochondrial enhancer: a new class of psychoactive drugs? Braz. J. Psychiatry 33, 321–322 (2011).

181. Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases.

Med. Hypotheses 56, 472–477 (2001).

182. Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radical Biology and

Medicine 130, 379–396 (2019).

183. Pezzuto, J. M. Resveratrol: Twenty Years of Growth, Development and Controversy. Biomol.

Ther.  27, 1–14 (2019).

184. M Andrea Markus, B. J. M. Resveratrol in prevention and treatment of common clinical conditions of aging. Clin. Interv. Aging 3, 331 (2008).

185. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating

SIRT1 and PGC-1α. Cell 127, 1109–1122 (2006).

186. Maroon, J. The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and

Healthier Life. (Simon and Schuster, 2008).

187. Evans, H., Howe, P. & Wong, R. Clinical Evaluation of Effects of Chronic Resveratrol

Supplementation on Cerebrovascular Function, Cognition, Mood, Physical Function and General Well-

Being in Postmenopausal Women—Rationale and Study Design. Nutrients vol. 8 150 (2016).

188. Grant, R. Resveratrol Increases Intracellular NAD Levels Through Up regulation of The NAD Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase. Nature Precedings (2010) doi:10.1038/npre.2010.4421.1.

189. Carrizzo, A. et al. Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. Food Chem. Toxicol. 61, 215–226 (2013).

190. Xia, N., Daiber, A., Förstermann, U. & Li, H. Antioxidant effects of resveratrol in the cardiovascular system. Br. J. Pharmacol. 174, 1633–1646 (2017).

191. Omidian, M. et al. The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis on Randomized Clinical Trials. Endocr. Metab. Immune Disord. Drug Targets (2019) doi:10.2174/1871530319666191116112950.

192. Khan, N. et al. Resveratrol and Bioactive Flavonoids in Immune Function. Dietary Components and

Immune Function 397–420 (2010) doi:10.1007/978-1-60761-061-8_23.

193. Inoue, H. & Nakata, R. Resveratrol Targets in Inflammation. Endocrine, Metabolic & Immune

Disorders-Drug Targets vol. 15 186–195 (2015).

194. Hurley, L. L., Akinfiresoye, L., Kalejaiye, O. & Tizabi, Y. Antidepressant effects of resveratrol in an animal model of depression. Behavioural Brain Research vol. 268 1–7 (2014).

195. pubmeddev & Lagouge M, E. al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. - PubMed - NCBI.

https://www.ncbi.nlm.nih.gov/pubmed/17112576.

196. Kan, N.-W. et al. The Synergistic Effects of Resveratrol combined with Resistant Training on

Exercise Performance and Physiological Adaption. Nutrients 10, (2018).

197. Alway, S. E. et al. Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of

Skeletal Muscle in Older Men and Women. J. Gerontol. A Biol. Sci. Med. Sci. 72, 1595–1606 (2017).

198. Scholey, A., Benson, S., Stough, C. & Stockley, C. Effects of resveratrol and alcohol on mood and cognitive function in older individuals. Nutrition and Aging vol. 2 133–138 (2014).

199. Merry, T. L. & Ristow, M. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J. Physiol. 594, 5135–5147 (2016).